Rebels in Congo reach door of Goma

GOMA, Congo (AP) — A Rwandan-backed rebel group advanced to within 3 kilometers (1.8 miles) of Goma, a crucial provincial capital in eastern Congo, marking the first time that rebels have come this close since 2008.

Congolese army spokesman Col. Olivier Hamuli said the fighting has been going on since 6 a.m. Sunday and the front line has moved to just a few kilometers (miles) outside the city. After more than nine hours of violent clashes the two sides took a break, with M23 rebels establishing a checkpoint just 100 meters (yards) away from one held by the military in the village of Munigi, exactly 3 kilometers (1.8 miles) outside the Goma city line.

Contacted by telephone on the front line, M23 rebel spokesman Col. Vianney Kazarama said the group will spend the night in Goma.

“We are about to take the town. We will spend the night in Goma tonight,” said Kazarama. “We are confident that we can take Goma and then our next step will be to take Bukavu,” he said mentioning the capital of the next province to the south.

The M23 rebel group is made up of soldiers from a now-defunct rebel army, the National Congress for the Defense of the People, or CNDP, a group made-up primarily of fighters from the Tutsi ethnic group, the ethnicity that was targeted in Rwanda‘s 1994 genocide. In 2008, the CNDP led by Rwandan commando Gen. Laurent Nkunda marched his soldiers to the doorstep of Goma, abruptly stopping just before taking the city.

In the negotiations that followed and which culminated in a March 23, 2009 peace deal, the CNDP agreed to disband and their fighters joined the national army of Congo. They did not pick up their arms again until this spring, when hundreds of ex-CNDP fighters defected from the army in April, claiming that the Congolese government had failed to uphold their end of the 2009 agreement.

Reports, including one by the United Nations Group of Experts, have shown that M23 is actively being backed by Rwanda and the new rebellion is likely linked to the fight to control Congo’s rich mineral wealth.

The latest fighting broke out Thursday and led to the deaths of 151 rebels and two soldiers. On Saturday U.N. attack helicopters targeted M23 positions in eastern Congo.

Also on Saturday, United Nations Secretary-General Ban Ki-Moon had called Rwandan President Paul Kagame “to request that he use his influence on the M23 to help calm the situation and restrain M23 from continuing their attack,” according to peacekeeping chief Herve Ladsous who spoke at the U.N. headquarters in New York on Saturday.

North Kivu governor Julien Paluku said Saturday that the Congolese army had earlier retreated from Kibumba, which is 30 kilometers (19 miles) north of Goma, after thousands of Rwandans, who he says were backing the rebels, attacked early Saturday.

“Rwandan forces bombarded our positions in Kibumba since early this morning and an estimated 3,500 crossed the border to attack us,” he said Saturday.

In downtown Goma, panicked residents had come out to try to get more information on what was happening. A 45-year-old mother of five said that she has nowhere to go.

“I don’t really know what is happening, I’ve seen soldiers and tanks in the streets and that scares me,” said Imaculee Kahindo. Asked if she planned to leave the city, she said: “What can we do? I will probably hide in my house with my children.”

Hamuli, the spokesman for the Congolese army, denied reports that soldiers were fleeing.

In 2008 as Nkunda’s CNDP rebels amassed at the gates of Goma, reporters inside the city were able to see Congolese soldiers running in the opposite direction, after having abandoned their posts. The Congolese army is notoriously dysfunctional with soldiers paid only small amounts, making it difficult to secure their loyalties during heavy fighting.

“We are fighting 3 kilometers from Goma, just past the airport. And our troops are strong enough to resist the rebels,” said Hamuli. “We won’t let the M23 march into our town,” he said. Asked if his troops were fleeing, he added: “These are false rumors. We are not going anywhere.”

U.N. peacekeeping chief Ladsous said that the rebels were very well-equipped, including with night vision equipment allowing them to fight at night.

Reports by United Nations experts have accused Rwanda, as well as Uganda, of supporting the rebels. Both countries strongly deny any involvement and Uganda said if the charges continue it will pull its peacekeeping troops out of Somalia, where they are playing an important role in pushing out the Islamist extremist rebels.

The U.N. Security Council called for an immediate stop to the violence following a two-hour, closed-door emergency meeting. The council said it would add sanctions against M23 rebels and demanded that rebels immediately stop their advance toward the provincial capital of Goma.

“We must stop the M23″ because Goma’s fall “would, inevitably, turn into a humanitarian crisis,” said France‘s U.N. Ambassador, Gerard Araud. He added that U.N. officials would decide in the coming days which M23 leaders to target for additional sanctions.

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Associated Press writer Maria Sanminiatelli at the United Nations and Rukmini Callimachi in Dakar, Senegal, contributed to this report.

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Singing stars arrive for American Music Awards

Pink on a song with Lauryn Hill? The pop star hopes so.

Pink said on the red carpet of the American Music Awards that she’d like to collaborate with the acclaimed singer-rapper.

Cyndi Lauper said her musical playlist includes Pink, Nicki Minaj and Carly Rae Jepsen‘s “Call Me Maybe.” Boy band The Wanted is excited to see “Gangnam Style” star PSY and Colbie Caillat wants to watch No Doubt rock the stage.

The stars walking the red carpet before the AMAs were ready to take their seats as fans. Arrivals included Taylor Swift, 50 Cent, Gloria Estefan, Ludacris, Kelly Rowland, Lady Antebellum, J. Cole, Luke Bryan, the Backstreet Boys and Linkin Park.

“What makes the American Music Awards special is the fans choose the winning artists,” said Chester Bennington of Linkin Park, who is nominated for favorite artist alternative rock and will perform at the show.

Carrie Underwood arrived in a magenta dress and Kerry Washington was in a banana Stella McCartney number Sunday. Heidi Klum and Ginnifer Goodwin were also on the scene.

Along with Rihanna, Minaj is the top nominee at Sunday’s American Music Awards, but the rapper-singer isn’t concerned with her four nominations.

“I don’t do music for awards,” the 29-year-old said in an interview. “It’s so crazy because people always have to remind me that I’m nominated for an award when I go to award shows.”

“I know they’re going to come. I’m sitting here looking at my awards right now,” she continued with a laugh. “I never stress it. I think of myself as ‘I’ll have a career long enough to get all those different awards.’”

In the pop/rock category, Minaj is up for favorite female artist and album for “Pink Friday: Roman Reloaded.” She’s also nominated for favorite artist and album in the hip-hop/rap category, two awards she won last year.

Minaj isn’t up for the night’s top award, though. Rihanna, Maroon 5, Drake, Katy Perry and Justin Bieber will battle it out for artist of the year.

But the American Music Awards are all about performances, and Sunday’s show will be no exception. Taylor Swift and Carrie Underwood will perform. Justin Bieber will share the stage with Minaj. Ludacris and Chris Brown will perform with Swizz Beatz. And Stevie Wonder is set to provide the soundtrack for a tribute to the late Dick Clark.

“I’m really going there to perform ‘Freedom,’” Minaj said of her new single. “I’m very, very proud of the record and I’m happy that people are going to get to hear it. I’m performing a hip-hop song on the AMAs, and I think . that’s just a big look for hip-hop.”

Rae Jepsen, Kelly Clarkson and Usher are also among those set to sing during the three-hour program, which is to be broadcast live on ABC.

Other multiple nominees include Usher, Bieber, Drake, Maroon 5 and One Direction, who have three nods each. Perry, Underwood, Brown, Clarkson, Pitbull, fun., Gotye, J. Cole and Luke Bryan are all double nominees.

American Music Awards nominees were selected based on sales and airplay, and fans chose the winners by voting online.

The 40th anniversary show will also include the tribute to Clark, its creator.

“Dick changed the face of music back in the late ’50s,” producer Larry Klein said. “Dick is the one who made rock ‘n’ roll acceptable to come into people’s homes… We’re paying tribute to Dick because of the legacy that he’s left everybody and also the creativity of what he did on this show.”

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AP Entertainment Writer Sandy Cohen contributed to this report from Los Angeles. Follow (at)APSandy’s American Music Award updates at www.twitter.com/APEntertainment.

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Online:

http://beta.abc.go.com/shows/american-music-awards

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Four year bans proposed under new WADA Code

(Reuters) – Athletes guilty of serious doping offenses will be suspended for four years from 2015 under proposals being considered by the World Anti-Doping Agency (WADA), but there are no plans for a specific rule to ban offenders from the Olympics.

Currently, athletes found guilty of a first major doping offense are handed a two-year ban with any subsequent positive test incurring a life-ban.

The longer ban would be introduced for offenses that include the use of anabolic steroids, human growth hormone, masking agents and trafficking, according to a second draft of the 2015 WADA code which was reviewed over the weekend.

“It is clear … there is a strong desire in the world of sport, from governments and within the anti-doping community to strengthen the sanction articles in the code,” WADA President John Fahey said in a statement.

“This second draft has done that, doubling the length of suspension for serious offenders and widening the scope for anti-doping organizations to impose lifetime bans.”

The draft does not, however, consider a former International Olympic Committee (IOC) rule regarding Olympic participation, which was ruled in non-compliance with the WADA Code in 2011 by sport’s highest court, the Court of Arbitration for Sport (CAS).

The IOC rule, introduced in 2008, banned athletes from participating at the next Olympic Games if they had been suspended for six months or longer.

After the rule was ruled non-compliant, Britain was forced to overturn lifetime Olympic bans on their drug cheats.

“The rational is if more four-year sanctions are delivered, then there won’t be any need for (the IOC rule) because the athletes will be missing the next Olympics,” WADA spokesman Terence O’Rorke said by telephone from Montreal.

The new WADA Code draft also includes a proposal that to be prohibited, substances or methods must be performance enhancing, contrary to the spirit of sport or contrary to the health of athletes.

The proposed code will undergo further review between now and March 2013, when it will be presented to the WADA Foundation Board before a final draft is prepared for ratification at the world anti-doping conference in Johannesburg next November.

“Athletes must know that there is a heavy price to pay for intentional doping,” Fahey said. “I am confident this draft will deliver that message loud and clear.”

WADA also said its funding would be frozen for a second successive year at approximately $ 28 million in 2013.

“This freeze is not ideal for the fight against doping in sport,” Fahey said. “It is widely accepted that doping is a major issue no longer restricted to the sporting world, and that it must be addressed by society as a whole.”

(Reporting by Gene Cherry in Salvo, North Carolina, editing by Nick Mulvenney)

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Israeli air strike kills 11 civilians in Gaza

GAZA/JERUSALEM (Reuters) - An Israeli missile killed at least 11 Palestinian civilians including four children in Gaza on Sunday, medical officials said, apparently an attack on a top militant that brought a three-storey home crashing down.

International pressure for a ceasefire seemed certain to mount in response to the deadliest single incident in five days of Palestinian rocket attacks on Israel and Israeli air strikes on the Gaza Strip.

Egypt has taken the lead in trying to broker a ceasefire and Israeli media said a delegation from Israel had been to Cairo for talks on ending the fighting, although a government spokesman declined to comment on the matter.

Egyptian President Mohamed Mursi met Hamas political leader Khaled Meshaal and Islamic Jihad's head Ramadan Shallah as part of the mediation efforts, but a presidency statement did not say if they were conclusive.

Izzat Risheq, a close aide to Meshaal, wrote in a Facebook message that Hamas would agree to a ceasefire only after Israel "stops its aggression, ends its policy of targeted assassinations and lifts the blockade of Gaza".

Listing Israel's terms for ceasing fire, Moshe Yaalon, a deputy to the prime minister, wrote on Twitter: "If there is quiet in the south and no rockets and missiles are fired at Israel's citizens, nor terrorist attacks engineered from the Gaza Strip, we will not attack."

Gaza health officials said 72 Palestinians , 21 of them children and several women have been killed in Gaza since Israel's offensive began. Hundreds have been wounded.

Israel gave off signs of a possible ground invasion of the Hamas-run enclave as the next stage in its offensive, billed as a bid to stop Palestinian rocket fire into the Jewish state. It also spelt out its conditions for a truce.

U.S. President Barack Obama said that while Israel had a right to defend itself against the salvoes, it would be "preferable" to avoid a military thrust into the Gaza Strip, a narrow, densely populated coastal territory. Such an assault would risk high casualties and an international outcry.

A spokesman for the Hamas-run Interior Ministry said 11 people, all of them civilians, were killed when an Israeli missile flattened the home of the Dalu family. Medics said four women and four children were among the dead.

Israel's chief military spokesman said Yihia Abayah, a senior commander of rocket operations in the Gaza Strip, had been the target.

The spokesman, Yoav Mordechai, told Israel's Channel 2 television he did not know whether Abayah was killed, "but the outcome was that there were civilian casualties". He made no direct mention of the destroyed dwelling.

Prime Minister Benjamin Netanyahu said earlier that he had assured world leaders that Israel was doing its utmost to avoid causing civilian casualties in the military showdown with Hamas.

"The massacre of the Dalu family will not pass without punishment," Hamas's armed wing said in a statement.

VIOLENCE

In other air raids on Sunday, two Gaza City media buildings were hit, witnesses said. Eight journalists were wounded and facilities belonging to Hamas's Al-Aqsa TV as well as Britain's Sky News were damaged.

An employee of the Beirut-based al Quds television station lost his leg in the attack, local medics said.

The Israeli military said the strike targeted a rooftop "transmission antenna used by Hamas to carry out terror activity", and that journalists in the building had effectively been used as human shields by Gaza's rulers.

For their part, Gaza militants launched dozens of rockets into Israel and targeted its commercial capital, Tel Aviv, for a fourth day, once in the morning and another after dark.

Israel's "Iron Dome" missile shield shot down all three rockets, but falling debris from the daytime interception hit a car, which caught fire. Its driver was not hurt.

In scenes recalling Israel's 2008-2009 winter invasion of Gaza, tanks, artillery and infantry massed in field encampments along the sandy, fenced-off border. Military convoys moved on roads in the area newly closed to civilian traffic.

Netanyahu said Israel was ready to widen its offensive.

"We are exacting a heavy price from Hamas and the terrorist organisations and the Israel Defence Forces are prepared for a significant expansion of the operation," he said at a cabinet meeting, giving no further details.

The Israeli military said 544 rockets fired from Gaza have hit Israel since Wednesday, killing three civilians and wounding dozens. Some 302 were intercepted and 99 failed to reach Israel and landed inside the Gaza Strip, it added.

Israel's declared goal is to deplete Gaza arsenals and force the Islamist Hamas to stop rocket fire that has bedevilled Israeli border towns for years and is now displaying greater range, putting Tel Aviv and Jerusalem in the crosshairs.

Israel withdrew settlers from Gaza in 2005 and two years later Hamas took control of the impoverished enclave, which the Israelis have kept under blockade.

OBAMA CAUTIONS AGAINST GROUND CAMPAIGN

At a news conference during a visit to the Thai capital Bangkok, Obama said Israel has "every right to expect that it does not have missiles fired into its territory".

He added: "If this can be accomplished without a ramping up of military activity in Gaza that is preferable. That's not just preferable for the people of Gaza, it's also preferable for Israelis because if Israeli troops are in Gaza they're much more at risk of incurring fatalities or being wounded," he said.

Obama said he had been in regular contact with Egyptian and Turkish leaders - to secure their mediation in bringing about a halt to rocket barrages by Hamas and other Islamist militants.

"We're going to have to see what kind of progress we can make in the next 24, 36, 48 hours," he added.

Diplomatic efforts continued on Sunday when French Foreign Minister Laurent Fabius met Israeli officials and Palestinian President Mahmoud Abbas in the West Bank.

"It is absolutely necessary that we move urgently towards a ceasefire, and that's where France can be useful," Fabius told French television, adding that war must be avoided.

U.N. Secretary-General Ban Ki-moon will be in Egypt on Monday for talks with Mursi, the foreign ministry in Cairo said. U.N. diplomats earlier said Ban was expected in Israel and Egypt this week to push for an end to the fighting.

Israel's operation has so far drawn Western support for what U.S. and European leaders have called its right to self-defence, but there was also a growing number of appeals from them to seek an end to the hostilities.

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Israel hits Hamas buildings, shoots down Tel Aviv-bound rocket

GAZA/JERUSALEM (Reuters) – Israeli aircraft bombed Hamas government buildings in Gaza, and the “Iron Dome” defense system shot down a Tel Aviv-bound rocket on Saturday as Israel geared up for a possible ground invasion.

Hamas, the Palestinian Islamist group that runs the Gaza Strip, said Israeli missiles wrecked the office building of Prime Minister Ismail Haniyeh – where he had met on Friday with the Egyptian prime minister – and struck a police headquarters.

Along the Tel Aviv beachfront, volleyball games came to an abrupt halt and people crouched as sirens sounded. Two interceptor rockets streaked into the sky. A flash and an explosion followed as Iron Dome, deployed only hours earlier near the city, destroyed the incoming projectile in mid-air.

With Israeli tanks and artillery positioned along the Gaza border and no end in sight to hostilities now in their fourth day, Tunisia’s foreign minister travelled to the enclave in a show of Arab solidarity.

In Cairo, a presidential source said Egyptian President Mohamed Mursi would hold four-way talks with the Qatari emir, the prime minister of Turkey and Hamas chief Khaled Meshaal in the Egyptian capital on Saturday to discuss the Gaza crisis.

Egypt has been working to reinstate calm between Israel and Hamas after an informal ceasefire brokered by Cairo unraveled over the past few weeks. Meshaal, who lives in exile, has already held a round of talks with Egyptian security officials.

Officials in Gaza said 43 Palestinians, nearly half of them civilians including eight children, had been killed since Israel began its air strikes. Three Israeli civilians were killed by a rocket on Thursday.

Israel unleashed its massive air campaign on Wednesday with the declared goal of deterring Hamas from launching rockets that have plagued its southern communities for years.

The Israeli army said it had zeroed in on a number of government buildings during the night, including Haniyeh’s office, the Hamas Interior Ministry and a police compound.

Taher al-Nono, a spokesman for the Hamas government, held a news conference near the rubble of the prime minister’s office and pledged: “We will declare victory from here.”

Hamas‘s armed wing claimed responsibility for Saturday’s rocket attack on Tel Aviv, the third against the city since Wednesday. It said it fired an Iranian-designed Fajr-5 at the coastal metropolis, some 70 km (43 miles) north of Gaza.

“Well that wasn’t such a big deal,” said one woman, who had watched the interception while clinging for protection to the trunk of a baby palm tree on a traffic island.

In the Israeli Mediterranean port of Ashdod, a rocket ripped into several balconies. Police said five people were hurt.

Among those killed in airstrikes on Gaza on Saturday were at least four suspected militants riding on motorcycles.

Israel’s operation has drawn Western support for what U.S. and European leaders have called Israel’s right to self-defense, along with appeals to avoid civilian casualties.

Hamas, shunned by the West over its refusal to recognize Israel, says its cross-border attacks have come in response to Israeli strikes against Palestinian fighters in Gaza.

RESERVIST CALL-UP

At a late night session on Friday, Israeli cabinet ministers decided to more than double the current reserve troop quota set for the Gaza offensive to 75,000, political sources said, in a signal Israel was edging closer to an invasion.

Around 16,000 reservists have already been called up.

Asked by reporters whether a ground operation was possible, Major-General Tal Russo, commander of the Israeli forces on the Gaza frontier, said: “Definitely.”

“We have a plan … it will take time. We need to have patience. It won’t be a day or two,” he added.

A possible move into the densely populated Gaza Strip and the risk of major casualties it brings would be a significant gamble for Prime Minister Benjamin Netanyahu, favorite to win a January national election.

Hamas fighters are no match for the Israeli military. The last Gaza war, involving a three-week long Israeli air blitz and ground invasion over the New Year period of 2008-09, killed over 1,400 Palestinians, mostly civilians. Thirteen Israelis died.

But the Gaza conflagration has stirred the pot of a Middle East already boiling from two years of Arab revolution and a civil war in Syria that threatens to spread beyond its borders.

“Israel should understand that many things have changed and that lots of water has run in the Arab river,” Tunisian Foreign Minister Rafik Abdesslem said as he surveyed the wreckage from a bomb-blast site in central Gaza.

One major change has been the election of an Islamist government in Cairo that is allied with Hamas, potentially narrowing Israel’s manoeuvering room in confronting the Palestinian group. Israel and Egypt made peace in 1979.

“DE-ESCALATION”

Netanyahu spoke late on Friday with U.S. President Barack Obama for the second time since the offensive began, the prime minister’s office said in a statement.

“(Netanyahu) expressed his deep appreciation for the U.S. position that Israel has a right to defend itself and thanked him for American aid in purchasing Iron Dome batteries,” the statement added.

The two leaders have had a testy relationship and have been at odds over how to curb Iran’s nuclear program.

A White House official said on Saturday Obama called Turkish Prime Minister Tayyip Erdogan to discuss how the two countries could help bring an end to the Gaza conflict.

Ben Rhodes, White House deputy national security adviser, told reporters that Washington “wants the same thing as the Israelis want”, an end to rocket attacks from Gaza. He said the United States is emphasizing diplomacy and “de-escalation”.

In Berlin, a spokesman for German Chancellor Angela Merkel said she had spoken to Netanyahu and Egypt’s Mursi, stressing to the Israeli leader that Israel had a right to self-defense and that a ceasefire must be agreed as soon as possible to avoid more bloodshed.

U.N. Secretary-General Ban Ki-moon is expected to visit Israel and Egypt next week to push for an end to the fighting in Gaza, U.N. diplomats said on Friday.

The Israeli military said 492 rockets fired from Gaza have hit Israel since the operation began. Iron Dome intercepted another 245.

In Jerusalem, targeted by a Palestinian rocket on Friday for the first time in 42 years, there was little outward sign on the Jewish Sabbath that the attack had any impact on the usually placid pace of life in the holy city.

Some families in Gaza have abandoned their homes – some of them damaged and others situated near potential Israeli targets – and packed into the houses of friends and relatives.

(Additional reporting by Dan Williams and Douglas Hamilton in Tel Aviv, Allyn Fisher-Ilan in Jerusalem, Jeff Mason aboard Air Force One, Writing by Jeffrey Heller; editing by Crispian Balmer)

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Wii U Will Launch With 24 Games This Sunday

Assassin’s Creed III

A version of the latest chapter in the Assassin’s Creed saga, a week after it was released on other console.

Click here to view this gallery.

[More from Mashable: Xbox Live Celebrates 10 Years of Connecting Gamers]

Nintendo’s newest console is out this Sunday, and there are already people lining up outside retailers to get one.

There are 24 games available for the Wii U at launch. Some are highly anticipated Nintendo staples, like New Super Mario Brothers U, and some are interesting and creative titles from third-party developers, like Scribblenauts Unlimited and ZombiU. Many games already out on other systems are being released for the Wii U as well, including Assassin’s Creed III and NBA 2K13; some of these games even have extra functionality that’s been added to take advantage of the Wii U GamePad.

[More from Mashable: Competitive Gaming Seeing TV-Levels of Viewership in 2012]

If you don’t see a game in the gallery above that you thought was coming to the Wii U, it’s because many announced games will be available in the “launch window”, a broad period from now until March. That’s when games like Pikmin 3 and LEGO City Undercover will come out.

If you haven’t preordered a Wii U from a large retailer, many places will still have them available at launch day. Expect long lines at larger retailers though.

Are you planning on purchasing a Wii U this weekend, and what games do you most want to buy? Let us know in the comments.

This story originally published on Mashable here.

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Liam Neeson in negotiations for crime thriller “The All Nighter”

LOS ANGELES (TheWrap.com) – Liam Neeson is in negotiations to star in the crime thriller “The All Nighter (AKA Run All Night)” a person familiar with the situation has told TheWrap.

The story follows an aging hit man who, in order to protect his wife and son, must take on his former boss in a single night. He then winds up on the run from the mob and the authorities with his estranged son.

The film is being produced by Vertigo Entertainment‘s Roy Lee, along with Brooklyn Weaver for Warner Bros. which declined to comment. The studio acquired Brad Ingelsby‘s spec script “The All Nighter” in January for a reported six figure sum.

Neeson’s upcoming films include “Non-Stop” and “A Walk Among The Tombstones.” He will also be featured in a voice role in the upcoming film “Lego: The Piece of Resistance.”

Lee is working on a long-list of projects including Spike Lee’s remake of the South Korean thriller, “Oldboy,” which is currently filming. He is also producing the upcoming thriller “The Double Hour”; a feature film based on the hit video game “Deus-Ex Human Revolution”; “Lego: The Piece of Resistance,” and the action thriller “Sleepless Night,” which is also set up at Warner Bros. Weaver’s credits include “Thirteen” and “Picture Book.”

Ingelsby’s upcoming projects as a writer include “The Raid.” In 2008, he made another major spec deal for his revenge thriller “The Low Dweller,” which went to Relativity Media.

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Roche’s Avastin misses key data point in brain cancer study

ZURICH (Reuters) – Swiss drugmaker Roche’s cancer drug Avastin failed to make a statistically significant difference to survival rates of patients with a common form of brain cancer in a late-stage study, the company said on Saturday.

The Phase III AVAglio study presented at the Society for Neuro-Oncology congress in Washington on Saturday showed Avastin, combined with radiation and chemotherapy, reduced the risk of cancer worsening or death, the Basel-based drugmaker said in a news release.

But the drug did not reach statistical significance in overall survival, a key data point. Further data are expected next year, Roche said.

“The interim results for overall survival (OS), the other co-primary endpoint, did not reach statistical significance,” the company said in the statement.

Earlier data from the study published in August showed Avastin significantly extended progression-free survival of people with an aggressive form of brain cancer.

Avastin is Roche’s third-biggest seller and is approved to treat several types of cancer, including breast, kidney, colorectal and ovarian cancers.

(Reporting by Katharina Bart and Caroline Copley; editing by Jason Webb)

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Israel bombards Gaza Strip, shoots down rocket

GAZA CITY, Gaza Strip (AP) — Israel destroyed the headquarters of Hamas' prime minister and blasted a sprawling network of smuggling tunnels in the southern Gaza Strip on Saturday, broadening a blistering four-day-old offensive against the Islamic militant group even as diplomatic efforts to broker a cease-fire appeared to be gaining steam.

Hamas officials said a building used by Hamas for broadcasts was bombed and three people were injured. The injured were from Al Quds TV, a Lebanon-based television channel. The building is also used by foreign news outlets including Germany's ARD, Kuwait TV and the Italian RAI and others.

The Israeli military spokesman was not immediately aware of the strikes but said they were investigating.

In neighboring Egypt, President Mohammed Morsi hosted leaders from Hamas and two key allies, Qatar and Turkey, to seek a way to end the fighting.

"There are discussions about the ways to bring a cease-fire soon, but there are no guarantees until now," Morsi said at a news conference. He said he was working with Turkey, Arab countries, the U.S., Russia and western European countries to halt the fighting.

Israel launched the operation on Wednesday in what it said was an effort to end months of rocket fire out of the Hamas-ruled territory. It began the offensive with an unexpected airstrike that killed Hamas' powerful military chief, and since then has relentlessly targeted suspected rocket launchers and storage sites.

In all, 48 Palestinians, including 15 civilians, have been killed and more than 400 civilians wounded, according to medical officials.

Three Israeli civilians have been killed and more than 50 wounded.

Israeli military officials expressed satisfaction with their progress Saturday, claiming they have inflicted heavy damage to Hamas.

"Most of their capabilities have been destroyed," Maj. Gen. Tal Russo, Israel's southern commander, told reporters. Asked whether Israel is ready to send ground troops into Gaza, he said: "Absolutely."

"Most of their weapons are stored in civilian's homes, they launch rockets from residential areas. We do not want to hit civilians in Gaza but we do want to hit the hornets' nest of terror in Gaza," he said.

Footage released Saturday by the Islamic Jihad showed rockets being fired from a hidden bunker in a built-up area. It wasn't clear whether it was a residential neighborhood.

Israel's Deputy Foreign Minister Danny Ayalon told channel 1 TV that "Hamas is committing a double war crime, they are firing rockets at Israeli civilians while using Palestinian civilians as human shields."

The White House said President Barack Obama was also in touch with the Egyptian and Turkish leaders. The U.S. has solidly backed Israel so far.

Speaking on Air Force One, deputy national security adviser Ben Rhodes said that the White House believes Israel "has the right to defend itself" against attack and that the Israelis will make their own decisions about their "military tactics and operations."

Despite the bruising offensive, Israel has failed to slow the barrages of rockets from Gaza.

The Israeli military said 160 rockets were launched into Israel on Saturday, raising the total number to roughly 500 since this week's fighting began. Eight Israelis, including five civilians, were lightly wounded Saturday, the army said.

Israel carried out at least 300 airstrikes on Saturday, the military said, and it broadened its array of targets. One air raid flattened the three-story office building used by Hamas' prime minister, Ismail Haniyeh. He was not inside the building at the time.

In southern Gaza, aircraft went after the tunnels that militants use to smuggle in weapons and other contraband from neighboring Egypt. Tunnel operators said the intensity of the bombing was unprecedented, and that massive explosions could be heard kilometers (miles) away, both in Gaza and in Egypt.

The operators, speaking on condition of anonymity because of the illicit nature of their business, said they cannot approach the tunnel area to assess the damage, but the blasts appeared to be more powerful than in Israel's last major push to destroy the tunnels during a previous offensive four years ago. The tunnels are a key lifeline for Hamas, bringing in both weapons and supporting a lucrative trade that helps fund the group's activities.

Missiles also smashed into two small security facilities and the massive Hamas police headquarters in Gaza City, setting off a huge blaze that engulfed nearby houses and civilian cars parked outside, the Interior Ministry reported. No one was inside the buildings.

Early on Sunday, Gaza health official Ashraf al-Kidra said two teenagers were killed and ten people were injured when a building was hit.

Gaza residents reported heavy Israeli raids overnight.

Air attacks knocked out five electricity transformers, cutting off power to more than 400,000 people in southern Gaza, according to the Gaza electricity distribution company. People switched on backup generators for limited electrical supplies.

Hamas has unveiled an arsenal of more powerful, longer-range rockets this week, and for the first time has struck at Israel's two largest cities, Jerusalem and Tel Aviv. Both cities, more than 70 kilometers (45 miles) from Gaza, had previously been beyond rocket range.

In a psychological boost for Israel, a new rocket-defense system known as "Iron Dome" knocked down a rocket headed toward Tel Aviv, eliciting cheers from relieved residents huddled in fear after air raid sirens sounded in the city.

Associated Press video showed a plume of smoke following an intercepting missile out of a rocket-defense battery deployed near the city, followed by a burst of light overhead as it struck its target.

Police said a second rocket also targeted Tel Aviv. It was not clear where it landed or whether it was shot down. No injuries were reported. It was the third straight day the city was targeted.

Israel says the Iron Dome system has shot down some 250 of 500 rockets fired toward the country this week, most in southern Israel near Gaza.

Saturday's interception was the first time Iron Dome has been deployed in Tel Aviv. The battery was a new upgraded version that was only activated on Saturday, two months ahead of schedule, the Defense Ministry said.

Israel has vowed to stage a ground invasion, a scenario that would bring the scale of fighting closer to that of a war four years ago. Hamas was badly bruised during that conflict but has since restocked its arsenal with more and better weapons. Five years after seizing control of Gaza, it has also come under pressure from smaller, more militant groups to prove its commitment to fighting Israel as it turns its focus to governing the seaside strip.

Israel's Defense Minister Ehud Barak has authorized the emergency call-up of up to 75,000 reserve troops ahead of a possible ground offensive. Israel has massed thousands of troops and dozens of tanks and armored vehicles along the border in recent days.

Egypt, which is led by Hamas' parent movement, the Muslim Brotherhood, has been spearheading efforts to forge a cease-fire. Morsi has vowed to stand strong with the people of Gaza and this week recalled Cairo's ambassador from Israel to protest the offensive.

Quietly, though, non-Muslim Brotherhood members in Morsi's government are said to be pushing Hamas to end its rocket fire on Israel. Morsi is under pressure not to go too far and risk straining ties with Israel's ally, the United States.

The Hamas website said Saturday that its leader, Khaled Meshaal, met with the head of Egyptian intelligence for two hours Saturday in Cairo, a day after the Egyptian official was in the Gaza Strip trying to work out an end to the escalation in violence.

Hamas has not immediately accepted Egypt's proposal for a cease-fire, but the group's website said it could end its rocket fire if Israel agrees to end "all acts of aggression and assassination" and lift its five-year blockade on Gaza. Egypt will present the Hamas position to Israeli officials.

Israeli officials say they are not interested in a "timeout," and want firm guarantees that the rocket fire, which has paralyzed life in an area home to 1 million Israelis, finally ends. Past cease-fires have been short lived.

Israeli Prime Minister Benjamin Netanyahu said he spoke with the leaders of Britain, Poland, Portugal, Bulgaria to press his case. "No government in the world would allow a situation where its population lives under the constant threat of rockets," Netanyahu told them, according to a statement from his office.

The diplomatic activity in Cairo illustrated Hamas' rising influence in a changing Middle East. The Arab Spring has brought Islamists to power and influence across the region, helping Hamas emerge from years of isolation.

Morsi warned that a ground operation by Irael will have "repercussions" across the region. "All must realize the situation is different than before, and the people of the region now are different than before and the leaders are different than before," he said at a joint press conference with Turkey's Islamist prime minister, Recep Tayyip Erdogan. Erdogan, like Morsi, leads an Islamist government that has chilly diplomatic ties with Israel.

On Friday, Morsi sent his prime minister to Gaza on a solidarity mission with Hamas. And on Saturday, Tunisia's Foreign Minister Rafik Abdessalem visited Gaza as well.

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Joe Federman reported from Jerusalem. Associated Press writers Karin Laub in Gaza City and Aya Batrawy in Cairo contributed reporting.

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Israel moves on reservists after rockets target cities

GAZA/JERUSALEM (Reuters) – Israeli ministers were on Friday asked to endorse the call-up of up to 75,000 reservists after Palestinian militants nearly hit Jerusalem with a rocket for the first time in decades and fired at Tel Aviv for a second day.

The rocket attacks were a challenge to Israel‘s Gaza offensive and came just hours after Egypt‘s prime minister, denouncing what he described as Israeli aggression, visited the enclave and said Cairo was prepared to mediate.

Israel’s armed forces announced that a highway leading to the Gaza Strip and two roads bordering the enclave would be off-limits to civilian traffic until further notice.

Tanks and self-propelled guns were seen near the border area on Friday, and the military said it had already called 16,000 reservists to active duty.

Prime Minister Benjamin Netanyahu convened senior cabinet ministers in Tel Aviv after the rockets struck to decide on widening the Gaza campaign.

Political sources said ministers were asked to approve the mobilization of up to 75,000 reservists, in what could be preparation for a possible ground operation.

No decision was immediately announced and some commentators speculated in the Israeli media the move could be psychological warfare against Gaza’s Hamas rulers. A quota of 30,000 reservists had been set earlier.

Israel began bombing Gaza on Wednesday with an attack that killed the Hamas military chief. It says its campaign is in response to Hamas missiles fired on its territory. Hamas stepped up rocket attacks in response.

Israeli police said a rocket fired from Gaza landed in the Jerusalem area, outside the city, on Friday.

It was the first Palestinian rocket since 1970 to reach the vicinity of the holy city, which Israel claims as its capital, and was likely to spur an escalation in its three-day old air war against militants in Gaza.

Rockets nearly hit Tel Aviv on Thursday for the first time since Saddam Hussein’s Iraq fired them during the 1991 Gulf War. An air raid siren rang out on Friday when the commercial centre was targeted again. Motorists crouched next to cars, many with their hands protecting their heads, while pedestrians scurried for cover in building stairwells.

The Jerusalem and Tel Aviv strikes have so far caused no casualties or damage, but could be political poison for Netanyahu, a conservative favored to win re-election in January on the strength of his ability to guarantee security.

“The Israel Defence Forces will continue to hit Hamas hard and are prepared to broaden the action inside Gaza,” Netanyahu said before the rocket attacks on the two cities.

Asked about Israel massing forces for a possible Gaza invasion, Hamas spokesman Sami Abu Zuhri said: “The Israelis should be aware of the grave results of such a raid and they should bring their body bags.”

Officials in Gaza said 28 Palestinians had been killed in the enclave since Israel began the air offensive with the declared aim of stemming surges of rocket strikes that have disrupted life in southern Israeli towns.

The Palestinian dead include 12 militants and 16 civilians, among them eight children and a pregnant woman. Three Israelis were killed by a rocket on Thursday. A Hamas source said the Israeli air force launched an attack on the house of Hamas’s commander for southern Gaza which resulted in the death of two civilians, one a child.

SOLIDARITY VISIT

A solidarity visit to Gaza by Egyptian Prime Minister Hisham Kandil, whose Islamist government is allied with Hamas but also party to a 1979 peace treaty with Israel, had appeared to open a tiny window to emergency peace diplomacy.

Kandil said: “Egypt will spare no effort … to stop the aggression and to achieve a truce.”

But a three-hour truce that Israel declared for the duration of Kandil’s visit never took hold. Israel said 66 rockets launched from the Gaza Strip hit its territory on Friday and a further 99 were intercepted by the Iron Dome anti-missile system.

Israel denied Palestinian assertions that its aircraft struck while Kandil was in the enclave.

Israel Radio’s military affairs correspondent said the army’s Homefront Command had told municipal officials to make civil defence preparations for the possibility that fighting could drag on for seven weeks. An Israeli military spokeswoman declined to comment on the report.

The Gaza conflagration has stoked the flames of a Middle East already ablaze with two years of Arab revolution and a civil war in Syria that threatens to leap across borders.

It is the biggest test yet for Egypt’s new President Mohamed Mursi, a veteran Islamist politician from the Muslim Brotherhood who was elected this year after last year’s protests ousted military autocrat Hosni Mubarak.

Egypt’s Muslim Brotherhood are spiritual mentors of Hamas, yet Mursi has also pledged to respect Cairo’s 1979 peace treaty with Israel, seen in the West as the cornerstone of regional security. Egypt and Israel both receive billions of dollars in U.S. military aid to underwrite their treaty.

Mursi has vocally denounced the Israeli military action while promoting Egypt as a mediator, a mission that his prime minister’s visit was intended to further.

A Palestinian official close to Egypt’s mediators told Reuters Kandil’s visit “was the beginning of a process to explore the possibility of reaching a truce. It is early to speak of any details or of how things will evolve”.

Hamas fighters are no match for the Israeli military. The last Gaza war, involving a three-week long Israeli air blitz and ground invasion over the New Year period of 2008-2009, killed more than 1,400 Palestinians, mostly civilians. Thirteen Israelis died.

Tunisia’s foreign minister was due to visit Gaza on Saturday “to provide all political support for Gaza” the spokesman for the Tunisian president, Moncef Marzouki, said in a statement.

The United States asked countries that have contact with Hamas to urge the Islamist movement to stop its rocket attacks.

Hamas refuses to recognize Israel’s right to exist. By contrast, Palestinian President Mahmoud Abbas, who rules in the nearby West Bank, does recognize Israel, but peace talks between the two sides have been frozen since 2010.

Abbas’s supporters say they will push ahead with a plan to have Palestine declared an “observer state” rather than a mere “entity” at the United Nations later this month.

(Additional reporting by Maayan Lubell, Jeffrey Heller and Crispian Balmer in Jerusalem; Writing by Jeffrey Heller; Editing by Giles Elgood)

World News Headlines – Yahoo! News

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